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Neurobiology

Prof. Dr. rer. nat. Roland Brandt

Prof. Dr. rer. nat. Roland Brandt

Tel.: +49 541 969-2338
Fax: +49 541 969-2354
Sprechzeiten: Fr. 11-12 mit Voranmeldung sowie n. V.
Raum: 36/313

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Curriculum Vitae

Publikationen

Homepage

Research Mission

The research of the Department of Neurobiology focuses on the study of the development and degeneration of nerve cells on the molecular, cellular and systemic level. A large part of the working group is concerned with the mechanisms that underlie the course of Alzheimer's disease. A protein of the neuronal cytoskeleton, the tau protein, plays a key role in this, and we investigate its (mal) functions using "live cell imaging" methods in cell and tissue models.

Research topics

  • Molecular mechanisms of Alzheimer's disease
  • The cytoskeleton in the development and aging of nerve cells
  • Molecular mechanisms of cell stress

Model systems

  • Neural cell cultures
  • Organotypic brain slices
  • Transgenic mouse models

Methods

  • Cell and tissue cultures
  • Viral and non-viral gene transfer
  • "Live cell imaging" and algorithm-based image analysis
  • Extracellular recordings with a multi-electrode array

Selected Publications

  1. Hrynchak MV, Rierola M, Golovyashkina N, Penazzi L, Pump WC, David B, Sündermann F, Brandt R, Bakota L (2020) Chronic presence of oligomeric Aβ differentially modulates spine parameters in the hippocampus and cortex of mice with low APP transgene expression. Front Synaptic Neurosci, 12:16, doi: 10.3389/fnsyn.2020.00016. pdf
  2. Niewidok B*, Igaev M*, Pereira da Graca A, Strassner A, Lenzen C, Richter CP, Piehler J, Kurre R, Brandt R (2018) Single-molecule imaging reveals dynamic biphasic partition of RNA-binding proteins in stress granules. (*joint first authors) J Cell Biol, 217, 1303–1318, doi: 10.1083/jcb.201709007. pdf
  3. Gauthier-Kemper A*, Suárez Alonso M*, Sündermann F, Niewidok B, Fernandez MP, Bakota L, Heinisch JJ, Brandt R (2018) Annexins A2 and A6 interact with the extreme N-terminus of tau and thereby contribute to tau’s axonal localization (*joint first authors). J Biol Chem, 293, 8065-8076, doi: 10.1074/jbc.RA117.000490. pdf

Further principal investigators

Dr. Lidia Bakota