Vortrag von Philipp Kukura
Vortragstitel: "Unravelling biomolecular structure, interactions and dynamics with mass photometry"
Anlass: SFB Seminar
Host: Jacob Piehler
Beginn: 17.05.2022 - 16:15 Uhr
Ort: CellNanOs 38/201
Über den Vortragenden: Philipp Kukura ist ein Physikochemiker, der als Professor für biophysikalische Chemie an der Universität Oxford arbeitet und Fellow des Exeter College, Oxford, ist.
Inhalt des Vortrags: Interactions between biomolecules control the processes of life in health, and their malfunction in disease, making their characterization and quantification essential to our understanding of the underlying molecular mechanisms. A major challenge stems from the intrinsic heterogeneity of molecular machines and its correlation with function. I will introduce mass photometry (MP), the accurate mass measurement of individual biomolecules in solution by light scattering, which enables the study of stoichiometries, structure, energetics and kinetics by combining label-free detection and mass measurement. In addition to illustrating the fundamental and unique capabilities of MP, I will discuss recent applications to studies of biomolecular self-assembly and membrane-associated processes with molecular resolution, and provide a brief outlook as to likely future capabilities and investigations.