Top content

Talk by Edoardo D’Imprima

Title: "The potential and challenges of Volume Electron Microscopy for clinical research"
Occasion: CRC-Seminar
Start: 04.12.2025, 14:15
Location: CellNanOs, 38/201

About the speaker: Edoardo D'Imprima is the coordinator of the Correlative Light-Electron Microscopy (CLEM) Core facility at Humanitas Research Hospital in Milan.

Volume electron microscopy (vEM) enables nanometer-scale 3D visualization of biological systems and, within CLEM, can reveal cellular interactions and tissue organization inaccessible to traditional histology or 2D EM. Recent advances in FIB-SEM, array tomography, sample preparation, and automation now allow acquisition of large, high-quality human and model tissue volumes. Our work applies these tools to neuroimmunology, microbiota–host interactions, infertility, and biofilm eradication. However, clinical adoption is limited by throughput, reproducibility, data volume, and challenges in correlative imaging. Integrating standardized workflows, AI-based segmentation, and quantitative multimodal analysis will be essential for translating vEM into clinical research and diagnostics.