Talk by Philipp Kukura
Title: "Unravelling biomolecular structure, interactions and dynamics with mass photometry"
Occasion: SFB Seminar
Host: Jacob Piehler
Start: 17.05.2022 - 16:15
Location: CellNanOs 38/201
About the speaker: Philipp Kukura works at the Physical and Theoretical Chemistry Laboratory, Department of Chemistry, University of Oxford and at the Kavli Insitute for Nanoscience Discovery, University of Oxford.
Abstract of the talk: Interactions between biomolecules control the processes of life in health, and their malfunction in disease, making their characterization and quantification essential to our understanding of the underlying molecular mechanisms. A major challenge stems from the intrinsic heterogeneity of molecular machines and its correlation with function. I will introduce mass photometry (MP), the accurate mass measurement of individual biomolecules in solution by light scattering, which enables the study of stoichiometries, structure, energetics and kinetics by combining label-free detection and mass measurement. In addition to illustrating the fundamental and unique capabilities of MP, I will discuss recent applications to studies of biomolecular self-assembly and membrane-associated processes with molecular resolution, and provide a brief outlook as to likely future capabilities and investigations.